Rescuing AAV Gene Transfer from Neutralizing Antibodies
Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts the treatable patient population and efficacy...
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Humanizing AAV capsids through directed evolution
Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach Approaches to engineer...
Crossing the blood-brain barrier
Mapping structural features of certain AAVs that enable transport across the brain vasculature Effective gene delivery to the CNS by...
Using a CRISPR Screen to identify AAV Restriction Factor
A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes...
AAV Transduction in CNS influenced by Sialic Acid Dependence
Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses Central...
Ring Finger Protein a Regulator of AAV Transcription
Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription Adeno-associated viruses (AAV) are...
Engineering circular RNAs
Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo Circular RNAs (circRNAs) are...
