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Rescuing AAV Gene Transfer from Neutralizing Antibodies

Preexisting humoral immunity to recombinant adeno-associated virus (AAV) vectors restricts the treatable patient population and efficacy...

Humanizing AAV capsids through directed evolution

Coevolution of Adeno-associated Virus Capsid Antigenicity and Tropism through a Structure-Guided Approach Approaches to engineer...

Crossing the blood-brain barrier

Mapping structural features of certain AAVs that enable transport across the brain vasculature Effective gene delivery to the CNS by...

Using a CRISPR Screen to identify AAV Restriction Factor

A CRISPR Screen Identifies the Cell Polarity Determinant Crumbs 3 as an Adeno-associated Virus Restriction Factor in Hepatocytes...

AAV Transduction in CNS influenced by Sialic Acid Dependence

Modulation of Sialic Acid Dependence Influences the Central Nervous System Transduction Profile of Adeno-associated Viruses Central...

Ring Finger Protein a Regulator of AAV Transcription

Ring finger protein 121 is a potent regulator of adeno-associated viral genome transcription Adeno-associated viruses (AAV) are...

Engineering circular RNAs

Tissue-Dependent Expression and Translation of Circular RNAs with Recombinant AAV Vectors In Vivo Circular RNAs (circRNAs) are...

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