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Evolving adeno-associated viruses for gene transfer to the kidney via cross-species cycling of capsid libraries
Abstract The difficulty of delivering genes to the kidney has limited the translation of genetic medicines, particularly for the more...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Summary Genetic engineering of TÂ cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach...
Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts
Abstract Many viruses have evolved structured RNA elements that can influence transcript abundance and translational efficiency, and help...
Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer
Abstract Systemic dosing of adeno-associated viral (AAV) vectors poses potential risk of adverse side effects including complement...
Repurposing CRISPR-Cas13 systems for robust mRNA trans-splicing
Type VI CRISPR enzymes have been developed as programmable RNA-guided Cas proteins for eukaryotic RNA editing. Notably, Cas13 has been...
Capsid-mediated control of adeno-associated viral transcription determines host range
Adeno-associated virus (AAV) is a member of the genus Dependoparvovirus, which infects a wide range of vertebrate species. Here, we...
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