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Spatial and longitudinal tracking of enhancer-AAV vectors that target transgene expression to injured mouse myocardium
Tissue regeneration enhancer elements (TREEs) direct expression of target genes in injured and regenerating tissues. Additionally, TREEs...
Functional orthogonality of parvoviral phospholipase A2 domains in adeno-associated virus transduction
Dependoparvoviruses, which belong to the family Parvoviridae, Â are being developed as viral vectors for gene transfer. Notably, different...
Evolving adeno-associated viruses for gene transfer to the kidney via cross-species cycling of capsid libraries
Abstract The difficulty of delivering genes to the kidney has limited the translation of genetic medicines, particularly for the more...
In vivo engineering of murine T cells using the evolved adeno-associated virus variant Ark313
Summary Genetic engineering of TÂ cells in mouse models is essential for investigating immune mechanisms. We aimed to develop an approach...
Sub-genomic flaviviral RNA elements increase the stability and abundance of recombinant AAV vector transcripts
Abstract Many viruses have evolved structured RNA elements that can influence transcript abundance and translational efficiency, and help...
Engineered IgM and IgG cleaving enzymes for mitigating antibody neutralization and complement activation in AAV gene transfer
Abstract Systemic dosing of adeno-associated viral (AAV) vectors poses potential risk of adverse side effects including complement...
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